Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer

Mutations in 5’ untranslated regions (UTRs) have a functional role in gene expression in cancer. Here, the authors develop a sequencing-based high throughput functional assay named PLUMAGE and show the effects of these mutations on gene expression and their association with clinical outcomes in pros...

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Autores principales:	Yiting Lim, Sonali Arora, Samantha L. Schuster, Lukas Corey, Matthew Fitzgibbon, Cynthia L. Wladyka, Xiaoying Wu, Ilsa M. Coleman, Jeffrey J. Delrow, Eva Corey, Lawrence D. True, Peter S. Nelson, Gavin Ha, Andrew C. Hsieh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b09e659db3294cf0bec903efcd4f8344
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spelling	oai:doaj.org-article:b09e659db3294cf0bec903efcd4f83442021-12-02T18:34:08ZMultiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer10.1038/s41467-021-24445-62041-1723https://doaj.org/article/b09e659db3294cf0bec903efcd4f83442021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24445-6https://doaj.org/toc/2041-1723Mutations in 5’ untranslated regions (UTRs) have a functional role in gene expression in cancer. Here, the authors develop a sequencing-based high throughput functional assay named PLUMAGE and show the effects of these mutations on gene expression and their association with clinical outcomes in prostate cancer.Yiting LimSonali AroraSamantha L. SchusterLukas CoreyMatthew FitzgibbonCynthia L. WladykaXiaoying WuIlsa M. ColemanJeffrey J. DelrowEva CoreyLawrence D. TruePeter S. NelsonGavin HaAndrew C. HsiehNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yiting Lim Sonali Arora Samantha L. Schuster Lukas Corey Matthew Fitzgibbon Cynthia L. Wladyka Xiaoying Wu Ilsa M. Coleman Jeffrey J. Delrow Eva Corey Lawrence D. True Peter S. Nelson Gavin Ha Andrew C. Hsieh Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer
description	Mutations in 5’ untranslated regions (UTRs) have a functional role in gene expression in cancer. Here, the authors develop a sequencing-based high throughput functional assay named PLUMAGE and show the effects of these mutations on gene expression and their association with clinical outcomes in prostate cancer.
format	article
author	Yiting Lim Sonali Arora Samantha L. Schuster Lukas Corey Matthew Fitzgibbon Cynthia L. Wladyka Xiaoying Wu Ilsa M. Coleman Jeffrey J. Delrow Eva Corey Lawrence D. True Peter S. Nelson Gavin Ha Andrew C. Hsieh
author_facet	Yiting Lim Sonali Arora Samantha L. Schuster Lukas Corey Matthew Fitzgibbon Cynthia L. Wladyka Xiaoying Wu Ilsa M. Coleman Jeffrey J. Delrow Eva Corey Lawrence D. True Peter S. Nelson Gavin Ha Andrew C. Hsieh
author_sort	Yiting Lim
title	Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer
title_short	Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer
title_full	Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer
title_fullStr	Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer
title_full_unstemmed	Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer
title_sort	multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b09e659db3294cf0bec903efcd4f8344
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Multiplexed functional genomic analysis of 5’ untranslated region mutations across the spectrum of prostate cancer

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