Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells
MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.
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Nature Portfolio
2017
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oai:doaj.org-article:b0f080fc66334b75bcf387ce61d4e0bc2021-12-02T14:42:08ZStabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells10.1038/ncomms145992041-1723https://doaj.org/article/b0f080fc66334b75bcf387ce61d4e0bc2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14599https://doaj.org/toc/2041-1723MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.Jeffrey Y. W. MakWeijun XuRobert C. ReidAlexandra J. CorbettBronwyn S. MeehanHuimeng WangZhenjun ChenJamie RossjohnJames McCluskeyLigong LiuDavid P. FairlieNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
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Science Q |
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Science Q Jeffrey Y. W. Mak Weijun Xu Robert C. Reid Alexandra J. Corbett Bronwyn S. Meehan Huimeng Wang Zhenjun Chen Jamie Rossjohn James McCluskey Ligong Liu David P. Fairlie Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells |
description |
MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo. |
format |
article |
author |
Jeffrey Y. W. Mak Weijun Xu Robert C. Reid Alexandra J. Corbett Bronwyn S. Meehan Huimeng Wang Zhenjun Chen Jamie Rossjohn James McCluskey Ligong Liu David P. Fairlie |
author_facet |
Jeffrey Y. W. Mak Weijun Xu Robert C. Reid Alexandra J. Corbett Bronwyn S. Meehan Huimeng Wang Zhenjun Chen Jamie Rossjohn James McCluskey Ligong Liu David P. Fairlie |
author_sort |
Jeffrey Y. W. Mak |
title |
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells |
title_short |
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells |
title_full |
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells |
title_fullStr |
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells |
title_full_unstemmed |
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells |
title_sort |
stabilizing short-lived schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant t cells |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/b0f080fc66334b75bcf387ce61d4e0bc |
work_keys_str_mv |
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