Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.

Guardado en:
Detalles Bibliográficos
Autores principales: Jeffrey Y. W. Mak, Weijun Xu, Robert C. Reid, Alexandra J. Corbett, Bronwyn S. Meehan, Huimeng Wang, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Ligong Liu, David P. Fairlie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/b0f080fc66334b75bcf387ce61d4e0bc
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:b0f080fc66334b75bcf387ce61d4e0bc
record_format dspace
spelling oai:doaj.org-article:b0f080fc66334b75bcf387ce61d4e0bc2021-12-02T14:42:08ZStabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells10.1038/ncomms145992041-1723https://doaj.org/article/b0f080fc66334b75bcf387ce61d4e0bc2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14599https://doaj.org/toc/2041-1723MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.Jeffrey Y. W. MakWeijun XuRobert C. ReidAlexandra J. CorbettBronwyn S. MeehanHuimeng WangZhenjun ChenJamie RossjohnJames McCluskeyLigong LiuDavid P. FairlieNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jeffrey Y. W. Mak
Weijun Xu
Robert C. Reid
Alexandra J. Corbett
Bronwyn S. Meehan
Huimeng Wang
Zhenjun Chen
Jamie Rossjohn
James McCluskey
Ligong Liu
David P. Fairlie
Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells
description MAIT cells are activated by MR1 restricted antigens derived from riboflavin biosynthesis. Here the authors characterize MAIT cell antigenicity and synthesize a water stable antigen that activates human MAIT cellsin vitro and mouse MAIT cells in vivo.
format article
author Jeffrey Y. W. Mak
Weijun Xu
Robert C. Reid
Alexandra J. Corbett
Bronwyn S. Meehan
Huimeng Wang
Zhenjun Chen
Jamie Rossjohn
James McCluskey
Ligong Liu
David P. Fairlie
author_facet Jeffrey Y. W. Mak
Weijun Xu
Robert C. Reid
Alexandra J. Corbett
Bronwyn S. Meehan
Huimeng Wang
Zhenjun Chen
Jamie Rossjohn
James McCluskey
Ligong Liu
David P. Fairlie
author_sort Jeffrey Y. W. Mak
title Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells
title_short Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells
title_full Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells
title_fullStr Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells
title_full_unstemmed Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells
title_sort stabilizing short-lived schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant t cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b0f080fc66334b75bcf387ce61d4e0bc
work_keys_str_mv AT jeffreyywmak stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT weijunxu stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT robertcreid stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT alexandrajcorbett stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT bronwynsmeehan stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT huimengwang stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT zhenjunchen stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT jamierossjohn stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT jamesmccluskey stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT ligongliu stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
AT davidpfairlie stabilizingshortlivedschiffbasederivativesof5aminouracilsthatactivatemucosalassociatedinvarianttcells
_version_ 1718389772606504960