Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells

How murine tracheal mesenchyme is specified during development is unclear. Here, the authors show a Wnt pathway target, Tbx4, is needed but this is regulated by Wnt signals from neighbouring tracheal epithelial cells, and take advantage of this knowledge to generate tracheal cartilage and smooth mus...

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Autores principales: Keishi Kishimoto, Kana T. Furukawa, Agustin Luz-Madrigal, Akira Yamaoka, Chisa Matsuoka, Masanobu Habu, Cantas Alev, Aaron M. Zorn, Mitsuru Morimoto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b0fc5e624a2e420cabcc656783db13c2
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