Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells

How murine tracheal mesenchyme is specified during development is unclear. Here, the authors show a Wnt pathway target, Tbx4, is needed but this is regulated by Wnt signals from neighbouring tracheal epithelial cells, and take advantage of this knowledge to generate tracheal cartilage and smooth mus...

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Autores principales:	Keishi Kishimoto, Kana T. Furukawa, Agustin Luz-Madrigal, Akira Yamaoka, Chisa Matsuoka, Masanobu Habu, Cantas Alev, Aaron M. Zorn, Mitsuru Morimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b0fc5e624a2e420cabcc656783db13c2
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spelling	oai:doaj.org-article:b0fc5e624a2e420cabcc656783db13c22021-12-02T15:09:26ZBidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells10.1038/s41467-020-17969-w2041-1723https://doaj.org/article/b0fc5e624a2e420cabcc656783db13c22020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17969-whttps://doaj.org/toc/2041-1723How murine tracheal mesenchyme is specified during development is unclear. Here, the authors show a Wnt pathway target, Tbx4, is needed but this is regulated by Wnt signals from neighbouring tracheal epithelial cells, and take advantage of this knowledge to generate tracheal cartilage and smooth muscle on dish from mouse and human embryonic stem cells.Keishi KishimotoKana T. FurukawaAgustin Luz-MadrigalAkira YamaokaChisa MatsuokaMasanobu HabuCantas AlevAaron M. ZornMitsuru MorimotoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keishi Kishimoto Kana T. Furukawa Agustin Luz-Madrigal Akira Yamaoka Chisa Matsuoka Masanobu Habu Cantas Alev Aaron M. Zorn Mitsuru Morimoto Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells
description	How murine tracheal mesenchyme is specified during development is unclear. Here, the authors show a Wnt pathway target, Tbx4, is needed but this is regulated by Wnt signals from neighbouring tracheal epithelial cells, and take advantage of this knowledge to generate tracheal cartilage and smooth muscle on dish from mouse and human embryonic stem cells.
format	article
author	Keishi Kishimoto Kana T. Furukawa Agustin Luz-Madrigal Akira Yamaoka Chisa Matsuoka Masanobu Habu Cantas Alev Aaron M. Zorn Mitsuru Morimoto
author_facet	Keishi Kishimoto Kana T. Furukawa Agustin Luz-Madrigal Akira Yamaoka Chisa Matsuoka Masanobu Habu Cantas Alev Aaron M. Zorn Mitsuru Morimoto
author_sort	Keishi Kishimoto
title	Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells
title_short	Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells
title_full	Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells
title_fullStr	Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells
title_full_unstemmed	Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells
title_sort	bidirectional wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b0fc5e624a2e420cabcc656783db13c2
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Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells

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