Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue

ADP-ribosylation is a reversible post-translational protein modification involved in many cellular processes. Here the authors describe a sensitive approach for the analysis of ADP-ribosylation sites under physiologic conditions and identify lysine residues as in vivotargets of ADP-ribosylation.

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Auteurs principaux: Rita Martello, Mario Leutert, Stephanie Jungmichel, Vera Bilan, Sara C. Larsen, Clifford Young, Michael O. Hottiger, Michael L. Nielsen
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/b0ff57e8f5184691918e14e931684d52
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