Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation

Highlights • SFKs activity-mediated P2X7 receptor signaling facilitates CSD propagation via glutamatergic pathway and also promotes neuroinflammation. • P2X7 receptor/SFKs signaling can be targeted for migraine prophylaxis and therapy.

Guardado en:

Detalles Bibliográficos
Autores principales:	Lingdi Nie, Dongqing Ma, John P. Quinn, Minyan Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Migraine cortical spreading depression P2X7 receptor Src family kinases glutamatergic pathway neuroinflammation Medicine R
Acceso en línea:	https://doaj.org/article/b10f2349612542eea2abee1f3af21e42
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b10f2349612542eea2abee1f3af21e42
record_format	dspace
spelling	oai:doaj.org-article:b10f2349612542eea2abee1f3af21e422021-12-05T12:23:31ZSrc family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation10.1186/s10194-021-01359-81129-23691129-2377https://doaj.org/article/b10f2349612542eea2abee1f3af21e422021-12-01T00:00:00Zhttps://doi.org/10.1186/s10194-021-01359-8https://doaj.org/toc/1129-2369https://doaj.org/toc/1129-2377Highlights • SFKs activity-mediated P2X7 receptor signaling facilitates CSD propagation via glutamatergic pathway and also promotes neuroinflammation. • P2X7 receptor/SFKs signaling can be targeted for migraine prophylaxis and therapy.Lingdi NieDongqing MaJohn P. QuinnMinyan WangBMCarticleMigrainecortical spreading depressionP2X7 receptorSrc family kinasesglutamatergic pathwayneuroinflammationMedicineRENThe Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Migraine cortical spreading depression P2X7 receptor Src family kinases glutamatergic pathway neuroinflammation Medicine R
spellingShingle	Migraine cortical spreading depression P2X7 receptor Src family kinases glutamatergic pathway neuroinflammation Medicine R Lingdi Nie Dongqing Ma John P. Quinn Minyan Wang Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation
description	Highlights • SFKs activity-mediated P2X7 receptor signaling facilitates CSD propagation via glutamatergic pathway and also promotes neuroinflammation. • P2X7 receptor/SFKs signaling can be targeted for migraine prophylaxis and therapy.
format	article
author	Lingdi Nie Dongqing Ma John P. Quinn Minyan Wang
author_facet	Lingdi Nie Dongqing Ma John P. Quinn Minyan Wang
author_sort	Lingdi Nie
title	Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation
title_short	Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation
title_full	Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation
title_fullStr	Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation
title_full_unstemmed	Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation
title_sort	src family kinases activity is required for transmitting purinergic p2x7 receptor signaling in cortical spreading depression and neuroinflammation
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b10f2349612542eea2abee1f3af21e42
work_keys_str_mv	AT lingdinie srcfamilykinasesactivityisrequiredfortransmittingpurinergicp2x7receptorsignalingincorticalspreadingdepressionandneuroinflammation AT dongqingma srcfamilykinasesactivityisrequiredfortransmittingpurinergicp2x7receptorsignalingincorticalspreadingdepressionandneuroinflammation AT johnpquinn srcfamilykinasesactivityisrequiredfortransmittingpurinergicp2x7receptorsignalingincorticalspreadingdepressionandneuroinflammation AT minyanwang srcfamilykinasesactivityisrequiredfortransmittingpurinergicp2x7receptorsignalingincorticalspreadingdepressionandneuroinflammation
_version_	1718371979147345920

Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation

Ejemplares similares