Self-organization of human dorsal-ventral forebrain structures by light induced SHH

Organizing centers act to pattern surrounding tissues during embryogenesis through the secretion of morphogens. Here the authors model human organizers using light stimulus to geometrically confine SHH expression in differentiating hESCs, generating spatially resolved proximal distal patterns.

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Detalles Bibliográficos
Autores principales: Riccardo De Santis, Fred Etoc, Edwin A. Rosado-Olivieri, Ali H. Brivanlou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b12f2668d87e40dab43931a94022f9b3
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