Self-organization of human dorsal-ventral forebrain structures by light induced SHH

Organizing centers act to pattern surrounding tissues during embryogenesis through the secretion of morphogens. Here the authors model human organizers using light stimulus to geometrically confine SHH expression in differentiating hESCs, generating spatially resolved proximal distal patterns.

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Auteurs principaux:	Riccardo De Santis, Fred Etoc, Edwin A. Rosado-Olivieri, Ali H. Brivanlou
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/b12f2668d87e40dab43931a94022f9b3
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id	oai:doaj.org-article:b12f2668d87e40dab43931a94022f9b3
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spelling	oai:doaj.org-article:b12f2668d87e40dab43931a94022f9b32021-11-21T12:33:58ZSelf-organization of human dorsal-ventral forebrain structures by light induced SHH10.1038/s41467-021-26881-w2041-1723https://doaj.org/article/b12f2668d87e40dab43931a94022f9b32021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26881-whttps://doaj.org/toc/2041-1723Organizing centers act to pattern surrounding tissues during embryogenesis through the secretion of morphogens. Here the authors model human organizers using light stimulus to geometrically confine SHH expression in differentiating hESCs, generating spatially resolved proximal distal patterns.Riccardo De SantisFred EtocEdwin A. Rosado-OlivieriAli H. BrivanlouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Riccardo De Santis Fred Etoc Edwin A. Rosado-Olivieri Ali H. Brivanlou Self-organization of human dorsal-ventral forebrain structures by light induced SHH
description	Organizing centers act to pattern surrounding tissues during embryogenesis through the secretion of morphogens. Here the authors model human organizers using light stimulus to geometrically confine SHH expression in differentiating hESCs, generating spatially resolved proximal distal patterns.
format	article
author	Riccardo De Santis Fred Etoc Edwin A. Rosado-Olivieri Ali H. Brivanlou
author_facet	Riccardo De Santis Fred Etoc Edwin A. Rosado-Olivieri Ali H. Brivanlou
author_sort	Riccardo De Santis
title	Self-organization of human dorsal-ventral forebrain structures by light induced SHH
title_short	Self-organization of human dorsal-ventral forebrain structures by light induced SHH
title_full	Self-organization of human dorsal-ventral forebrain structures by light induced SHH
title_fullStr	Self-organization of human dorsal-ventral forebrain structures by light induced SHH
title_full_unstemmed	Self-organization of human dorsal-ventral forebrain structures by light induced SHH
title_sort	self-organization of human dorsal-ventral forebrain structures by light induced shh
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b12f2668d87e40dab43931a94022f9b3
work_keys_str_mv	AT riccardodesantis selforganizationofhumandorsalventralforebrainstructuresbylightinducedshh AT fredetoc selforganizationofhumandorsalventralforebrainstructuresbylightinducedshh AT edwinarosadoolivieri selforganizationofhumandorsalventralforebrainstructuresbylightinducedshh AT alihbrivanlou selforganizationofhumandorsalventralforebrainstructuresbylightinducedshh
_version_	1718418964477902848

Self-organization of human dorsal-ventral forebrain structures by light induced SHH

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