Mechanistic basis of L-lactate transport in the SLC16 solute carrier family

The transport of L-lactate across plasma membranes is catalyzed by proton-driven monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. Here, the authors present the crystal structures of a bacterial SLC16 homologue with the bound substrate L-lactate and ligand thiosalicylate both i...

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Autores principales:	Patrick D. Bosshart, David Kalbermatter, Sara Bonetti, Dimitrios Fotiadis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b140603bfee541c0b8f279a225e59172
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spelling	oai:doaj.org-article:b140603bfee541c0b8f279a225e591722021-12-02T15:35:13ZMechanistic basis of L-lactate transport in the SLC16 solute carrier family10.1038/s41467-019-10566-62041-1723https://doaj.org/article/b140603bfee541c0b8f279a225e591722019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10566-6https://doaj.org/toc/2041-1723The transport of L-lactate across plasma membranes is catalyzed by proton-driven monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. Here, the authors present the crystal structures of a bacterial SLC16 homologue with the bound substrate L-lactate and ligand thiosalicylate both in an outward-open conformation and discuss the L-lactate transport mechanism.Patrick D. BosshartDavid KalbermatterSara BonettiDimitrios FotiadisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patrick D. Bosshart David Kalbermatter Sara Bonetti Dimitrios Fotiadis Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
description	The transport of L-lactate across plasma membranes is catalyzed by proton-driven monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. Here, the authors present the crystal structures of a bacterial SLC16 homologue with the bound substrate L-lactate and ligand thiosalicylate both in an outward-open conformation and discuss the L-lactate transport mechanism.
format	article
author	Patrick D. Bosshart David Kalbermatter Sara Bonetti Dimitrios Fotiadis
author_facet	Patrick D. Bosshart David Kalbermatter Sara Bonetti Dimitrios Fotiadis
author_sort	Patrick D. Bosshart
title	Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
title_short	Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
title_full	Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
title_fullStr	Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
title_full_unstemmed	Mechanistic basis of L-lactate transport in the SLC16 solute carrier family
title_sort	mechanistic basis of l-lactate transport in the slc16 solute carrier family
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b140603bfee541c0b8f279a225e59172
work_keys_str_mv	AT patrickdbosshart mechanisticbasisofllactatetransportintheslc16solutecarrierfamily AT davidkalbermatter mechanisticbasisofllactatetransportintheslc16solutecarrierfamily AT sarabonetti mechanisticbasisofllactatetransportintheslc16solutecarrierfamily AT dimitriosfotiadis mechanisticbasisofllactatetransportintheslc16solutecarrierfamily
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Mechanistic basis of L-lactate transport in the SLC16 solute carrier family

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