The less conserved metal-binding site in human CRISP1 remains sensitive to zinc ions to permit protein oligomerization

Abstract Cysteine-rich secretory proteins (CRISPs) are a subgroup of the CRISP, antigen 5 and PR-1 (CAP) superfamily that is characterized by the presence of a conserved CAP domain. Two conserved histidines in the CAP domain are proposed to function as a Zn2+-binding site with unknown function. Huma...

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Autores principales: Jie Sheng, Bart M. Gadella, Nick K. Olrichs, Dora V. Kaloyanova, J. Bernd Helms
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b17809b3b0aa4614bc98b150707df310
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