Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

Dopamine release in the striatum has important roles in action selection and in disorders such as Parkinson’s disease. The authors here show that short-term plasticity of dopamine release is strongly determined by axonal activation and dopamine transporters.

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Auteurs principaux: Mark D. Condon, Nicola J. Platt, Yan-Feng Zhang, Bradley M. Roberts, Michael A. Clements, Stefania Vietti-Michelina, Min-Yee Tseu, Katherine R. Brimblecombe, Sarah Threlfell, Edward O. Mann, Stephanie J. Cragg
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/b1b396a19d0e49f0914ab423562f96e0
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Résumé:Dopamine release in the striatum has important roles in action selection and in disorders such as Parkinson’s disease. The authors here show that short-term plasticity of dopamine release is strongly determined by axonal activation and dopamine transporters.