5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients

Glioblastomas have distorted epigenomes. Here, the authors compare the genome-wide profiles of 5-methylcytosine and 5- hydroxymethylcytosine in glioblastoma and prefrontal cortex tissue reporting a correlation between these profiles and patients’ prognosis.

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Autores principales:	Kevin C. Johnson, E. Andres Houseman, Jessica E. King, Katharine M. von Herrmann, Camilo E. Fadul, Brock C. Christensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1fd49e9a254447bbb77068bd2d41e2b
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spelling	oai:doaj.org-article:b1fd49e9a254447bbb77068bd2d41e2b2021-12-02T16:57:18Z5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients10.1038/ncomms131772041-1723https://doaj.org/article/b1fd49e9a254447bbb77068bd2d41e2b2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13177https://doaj.org/toc/2041-1723Glioblastomas have distorted epigenomes. Here, the authors compare the genome-wide profiles of 5-methylcytosine and 5- hydroxymethylcytosine in glioblastoma and prefrontal cortex tissue reporting a correlation between these profiles and patients’ prognosis.Kevin C. JohnsonE. Andres HousemanJessica E. KingKatharine M. von HerrmannCamilo E. FadulBrock C. ChristensenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin C. Johnson E. Andres Houseman Jessica E. King Katharine M. von Herrmann Camilo E. Fadul Brock C. Christensen 5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients
description	Glioblastomas have distorted epigenomes. Here, the authors compare the genome-wide profiles of 5-methylcytosine and 5- hydroxymethylcytosine in glioblastoma and prefrontal cortex tissue reporting a correlation between these profiles and patients’ prognosis.
format	article
author	Kevin C. Johnson E. Andres Houseman Jessica E. King Katharine M. von Herrmann Camilo E. Fadul Brock C. Christensen
author_facet	Kevin C. Johnson E. Andres Houseman Jessica E. King Katharine M. von Herrmann Camilo E. Fadul Brock C. Christensen
author_sort	Kevin C. Johnson
title	5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients
title_short	5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients
title_full	5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients
title_fullStr	5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients
title_full_unstemmed	5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients
title_sort	5-hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b1fd49e9a254447bbb77068bd2d41e2b
work_keys_str_mv	AT kevincjohnson 5hydroxymethylcytosinelocalizestoenhancerelementsandisassociatedwithsurvivalinglioblastomapatients AT eandreshouseman 5hydroxymethylcytosinelocalizestoenhancerelementsandisassociatedwithsurvivalinglioblastomapatients AT jessicaeking 5hydroxymethylcytosinelocalizestoenhancerelementsandisassociatedwithsurvivalinglioblastomapatients AT katharinemvonherrmann 5hydroxymethylcytosinelocalizestoenhancerelementsandisassociatedwithsurvivalinglioblastomapatients AT camiloefadul 5hydroxymethylcytosinelocalizestoenhancerelementsandisassociatedwithsurvivalinglioblastomapatients AT brockcchristensen 5hydroxymethylcytosinelocalizestoenhancerelementsandisassociatedwithsurvivalinglioblastomapatients
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5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients

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