Easy access to both enantiomers of 5-hydroxyequol and 3-(4-hydroxyphenyl)chroman-8-ol
5-Hydroxyequol, a biologically active isoflavone metabolite from genistein, has been synthesized enantioselectively from 3-(2,4,6-trimethoxyphenyl)propanal by using MacMillans’ asymmetric α -arylation protocol of carbonyl compound. (S)- and (R)-5-Hydroxyequols have been obtained in 90% and 88% ee, r...
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| Main Authors: | , , |
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| Format: | article |
| Language: | EN |
| Published: |
Elsevier
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/b20805afb0e248c1ad06a0ee75183be5 |
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