Easy access to both enantiomers of 5-hydroxyequol and 3-(4-hydroxyphenyl)chroman-8-ol

5-Hydroxyequol, a biologically active isoflavone metabolite from genistein, has been synthesized enantioselectively from 3-(2,4,6-trimethoxyphenyl)propanal by using MacMillans’ asymmetric α -arylation protocol of carbonyl compound. (S)- and (R)-5-Hydroxyequols have been obtained in 90% and 88% ee, r...

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Autores principales: Takahito Uemura, Motohiro Sonoda, Shinji Tanimori
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/b20805afb0e248c1ad06a0ee75183be5
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