HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio

HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio

Abstract Background During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid lattice. HIV-1 integrase (IN) binds the viral genomic RNA (gRNA) and impairment of IN-gRNA binding leads to mis-localization of the nu...

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Autores principales: Shuohui Liu, Pratibha C. Koneru, Wen Li, Chathuri Pathirage, Alan N. Engelman, Mamuka Kvaratskhelia, Karin Musier-Forsyth
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
HIV-1
Nucleocapsid
Integrase
XL-SHAPE
5′-UTR
RNA binding
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/b25da067a5a5468487406fa1f1cc362a
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https://doaj.org/article/b25da067a5a5468487406fa1f1cc362a

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