Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Testis-restricted melanoma antigen (MAGE) proteins function as substrate adapters for E3 ubiquitin ligases. Biochemical and structural analyses of MAGE-A11 provide insight into the substrate binding mode of MAGE proteins and enable discovery of potent, cytotoxic inhibitors of MAGE-A11:substrate inte...

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Auteurs principaux: Seung Wook Yang, Xin Huang, Wenwei Lin, Jaeki Min, Darcie J. Miller, Anand Mayasundari, Patrick Rodrigues, Elizabeth C. Griffith, Clifford T. Gee, Lei Li, Wei Li, Richard E. Lee, Zoran Rankovic, Taosheng Chen, Patrick Ryan Potts
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/b277e39e14d144a186f5155bc60329ef
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Résumé:Testis-restricted melanoma antigen (MAGE) proteins function as substrate adapters for E3 ubiquitin ligases. Biochemical and structural analyses of MAGE-A11 provide insight into the substrate binding mode of MAGE proteins and enable discovery of potent, cytotoxic inhibitors of MAGE-A11:substrate interaction.

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