Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Testis-restricted melanoma antigen (MAGE) proteins function as substrate adapters for E3 ubiquitin ligases. Biochemical and structural analyses of MAGE-A11 provide insight into the substrate binding mode of MAGE proteins and enable discovery of potent, cytotoxic inhibitors of MAGE-A11:substrate inte...

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Autores principales:	Seung Wook Yang, Xin Huang, Wenwei Lin, Jaeki Min, Darcie J. Miller, Anand Mayasundari, Patrick Rodrigues, Elizabeth C. Griffith, Clifford T. Gee, Lei Li, Wei Li, Richard E. Lee, Zoran Rankovic, Taosheng Chen, Patrick Ryan Potts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b277e39e14d144a186f5155bc60329ef
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spelling	oai:doaj.org-article:b277e39e14d144a186f5155bc60329ef2021-12-02T17:37:14ZStructural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases10.1038/s41467-020-18708-x2041-1723https://doaj.org/article/b277e39e14d144a186f5155bc60329ef2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18708-xhttps://doaj.org/toc/2041-1723Testis-restricted melanoma antigen (MAGE) proteins function as substrate adapters for E3 ubiquitin ligases. Biochemical and structural analyses of MAGE-A11 provide insight into the substrate binding mode of MAGE proteins and enable discovery of potent, cytotoxic inhibitors of MAGE-A11:substrate interaction.Seung Wook YangXin HuangWenwei LinJaeki MinDarcie J. MillerAnand MayasundariPatrick RodriguesElizabeth C. GriffithClifford T. GeeLei LiWei LiRichard E. LeeZoran RankovicTaosheng ChenPatrick Ryan PottsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seung Wook Yang Xin Huang Wenwei Lin Jaeki Min Darcie J. Miller Anand Mayasundari Patrick Rodrigues Elizabeth C. Griffith Clifford T. Gee Lei Li Wei Li Richard E. Lee Zoran Rankovic Taosheng Chen Patrick Ryan Potts Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
description	Testis-restricted melanoma antigen (MAGE) proteins function as substrate adapters for E3 ubiquitin ligases. Biochemical and structural analyses of MAGE-A11 provide insight into the substrate binding mode of MAGE proteins and enable discovery of potent, cytotoxic inhibitors of MAGE-A11:substrate interaction.
format	article
author	Seung Wook Yang Xin Huang Wenwei Lin Jaeki Min Darcie J. Miller Anand Mayasundari Patrick Rodrigues Elizabeth C. Griffith Clifford T. Gee Lei Li Wei Li Richard E. Lee Zoran Rankovic Taosheng Chen Patrick Ryan Potts
author_facet	Seung Wook Yang Xin Huang Wenwei Lin Jaeki Min Darcie J. Miller Anand Mayasundari Patrick Rodrigues Elizabeth C. Griffith Clifford T. Gee Lei Li Wei Li Richard E. Lee Zoran Rankovic Taosheng Chen Patrick Ryan Potts
author_sort	Seung Wook Yang
title	Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
title_short	Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
title_full	Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
title_fullStr	Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
title_full_unstemmed	Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
title_sort	structural basis for substrate recognition and chemical inhibition of oncogenic mage ubiquitin ligases
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b277e39e14d144a186f5155bc60329ef
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Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

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