Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments

Regulated thin filaments (RTFs) tightly control striated muscle contraction through calcium binding to troponin, which enables tropomyosin to expose myosin-binding sites on actin. Myosin binding holds tropomyosin in an open position, exposing more myosin-binding sites on actin, leading to cooperativ...

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Autores principales: Quentin M Smith, Alessio V Inchingolo, Madalina-Daniela Mihailescu, Hongsheng Dai, Neil M Kad
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
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Acceso en línea:https://doaj.org/article/b292140cde184a14b4f0e4ce71ad097e
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