Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments

Regulated thin filaments (RTFs) tightly control striated muscle contraction through calcium binding to troponin, which enables tropomyosin to expose myosin-binding sites on actin. Myosin binding holds tropomyosin in an open position, exposing more myosin-binding sites on actin, leading to cooperativ...

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Auteurs principaux: Quentin M Smith, Alessio V Inchingolo, Madalina-Daniela Mihailescu, Hongsheng Dai, Neil M Kad
Format: article
Langue:EN
Publié: eLife Sciences Publications Ltd 2021
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R
Q
Accès en ligne:https://doaj.org/article/b292140cde184a14b4f0e4ce71ad097e
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