Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development
New tuberculosis therapies, targeting respiratory chain components of Mycobacterium tuberculosis, are under development. Here the authors show that, contrary to common belief, some of these components are not essential for pathogen viability and/or virulence in animal models of infection.
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Nature Portfolio
2019
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oai:doaj.org-article:b2df601988674fd2942c5f4b81e2ac982021-12-02T16:57:31ZPlasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development10.1038/s41467-019-12956-22041-1723https://doaj.org/article/b2df601988674fd2942c5f4b81e2ac982019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12956-2https://doaj.org/toc/2041-1723New tuberculosis therapies, targeting respiratory chain components of Mycobacterium tuberculosis, are under development. Here the authors show that, contrary to common belief, some of these components are not essential for pathogen viability and/or virulence in animal models of infection.Tiago BeitesKathryn O’BrienDivya TiwariCurtis A. EngelhartShaun WaltersJenna AndrewsHee-Jeong YangMichelle L. SutphenDanielle M. WeinerEmmanuel K. DayaoMatthew ZimmermanBrendan PrideauxPrashant V. DesaiThierry MasquelinLaura E. ViaVéronique DartoisHelena I. BoshoffClifton E. BarrySabine EhrtDirk SchnappingerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tiago Beites Kathryn O’Brien Divya Tiwari Curtis A. Engelhart Shaun Walters Jenna Andrews Hee-Jeong Yang Michelle L. Sutphen Danielle M. Weiner Emmanuel K. Dayao Matthew Zimmerman Brendan Prideaux Prashant V. Desai Thierry Masquelin Laura E. Via Véronique Dartois Helena I. Boshoff Clifton E. Barry Sabine Ehrt Dirk Schnappinger Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development |
| description |
New tuberculosis therapies, targeting respiratory chain components of Mycobacterium tuberculosis, are under development. Here the authors show that, contrary to common belief, some of these components are not essential for pathogen viability and/or virulence in animal models of infection. |
| format |
article |
| author |
Tiago Beites Kathryn O’Brien Divya Tiwari Curtis A. Engelhart Shaun Walters Jenna Andrews Hee-Jeong Yang Michelle L. Sutphen Danielle M. Weiner Emmanuel K. Dayao Matthew Zimmerman Brendan Prideaux Prashant V. Desai Thierry Masquelin Laura E. Via Véronique Dartois Helena I. Boshoff Clifton E. Barry Sabine Ehrt Dirk Schnappinger |
| author_facet |
Tiago Beites Kathryn O’Brien Divya Tiwari Curtis A. Engelhart Shaun Walters Jenna Andrews Hee-Jeong Yang Michelle L. Sutphen Danielle M. Weiner Emmanuel K. Dayao Matthew Zimmerman Brendan Prideaux Prashant V. Desai Thierry Masquelin Laura E. Via Véronique Dartois Helena I. Boshoff Clifton E. Barry Sabine Ehrt Dirk Schnappinger |
| author_sort |
Tiago Beites |
| title |
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development |
| title_short |
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development |
| title_full |
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development |
| title_fullStr |
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development |
| title_full_unstemmed |
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development |
| title_sort |
plasticity of the mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/b2df601988674fd2942c5f4b81e2ac98 |
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| _version_ |
1718382524609069056 |