Statin use and risk of diabetes mellitus
At present time four groups of medications are used to correct dyslipidemia: bile acid sequestrants, niacin, fibric acid derivatives andstatins. During last years statins' potential to increase risk of type 2 diabetes mellitus (T2DM) is actively discussed, though no commonopinion about the poss...
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Endocrinology Research Centre
2012
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oai:doaj.org-article:b31942a2c8ca41908837b15aa3f8aa172021-11-14T09:00:17ZStatin use and risk of diabetes mellitus2072-03512072-037810.14341/2072-0351-5523https://doaj.org/article/b31942a2c8ca41908837b15aa3f8aa172012-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5523https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378At present time four groups of medications are used to correct dyslipidemia: bile acid sequestrants, niacin, fibric acid derivatives andstatins. During last years statins' potential to increase risk of type 2 diabetes mellitus (T2DM) is actively discussed, though no commonopinion about the possible mechanism of such effect has evolved as yet. Insulin desensitizing effect as a class feature of statins remainsa disputable question.Position of statins as a first-line therapy for severe hyperlipidemia seems undoubted; however they do not improve insulin sensitivity.Moreover, several studies reported increased risk of T2DM. It is feasible to consider combined treatment (including metformin) inpatients from risk groups for development of T2DM, receiving statinsOksana Mikhailovna DrapkinaMarina Viktorovna KostyukevichEndocrinology Research Centrearticlestatinsinsulin resistancediabetes mellitusatherosclerosismetforminNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 2, Pp 77-82 (2012) |
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EN RU |
| topic |
statins insulin resistance diabetes mellitus atherosclerosis metformin Nutritional diseases. Deficiency diseases RC620-627 |
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statins insulin resistance diabetes mellitus atherosclerosis metformin Nutritional diseases. Deficiency diseases RC620-627 Oksana Mikhailovna Drapkina Marina Viktorovna Kostyukevich Statin use and risk of diabetes mellitus |
| description |
At present time four groups of medications are used to correct dyslipidemia: bile acid sequestrants, niacin, fibric acid derivatives andstatins. During last years statins' potential to increase risk of type 2 diabetes mellitus (T2DM) is actively discussed, though no commonopinion about the possible mechanism of such effect has evolved as yet. Insulin desensitizing effect as a class feature of statins remainsa disputable question.Position of statins as a first-line therapy for severe hyperlipidemia seems undoubted; however they do not improve insulin sensitivity.Moreover, several studies reported increased risk of T2DM. It is feasible to consider combined treatment (including metformin) inpatients from risk groups for development of T2DM, receiving statins |
| format |
article |
| author |
Oksana Mikhailovna Drapkina Marina Viktorovna Kostyukevich |
| author_facet |
Oksana Mikhailovna Drapkina Marina Viktorovna Kostyukevich |
| author_sort |
Oksana Mikhailovna Drapkina |
| title |
Statin use and risk of diabetes mellitus |
| title_short |
Statin use and risk of diabetes mellitus |
| title_full |
Statin use and risk of diabetes mellitus |
| title_fullStr |
Statin use and risk of diabetes mellitus |
| title_full_unstemmed |
Statin use and risk of diabetes mellitus |
| title_sort |
statin use and risk of diabetes mellitus |
| publisher |
Endocrinology Research Centre |
| publishDate |
2012 |
| url |
https://doaj.org/article/b31942a2c8ca41908837b15aa3f8aa17 |
| work_keys_str_mv |
AT oksanamikhailovnadrapkina statinuseandriskofdiabetesmellitus AT marinaviktorovnakostyukevich statinuseandriskofdiabetesmellitus |
| _version_ |
1718429605763743744 |