Reconciling qualitative, abstract, and scalable modeling of biological networks

Boolean Networks are a well-established model of biological networks, but usual interpretations can preclude the prediction of behaviours observed in quantitative systems. The authors introduce Most Permissive Boolean Networks, which are shown not to miss any behaviour achievable by the correspondin...

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Bibliographic Details
Main Authors: Loïc Paulevé, Juraj Kolčák, Thomas Chatain, Stefan Haar
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Q
Online Access:https://doaj.org/article/b334f95a292b43fca9da83ea0ae7f1a2
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Summary:Boolean Networks are a well-established model of biological networks, but usual interpretations can preclude the prediction of behaviours observed in quantitative systems. The authors introduce Most Permissive Boolean Networks, which are shown not to miss any behaviour achievable by the corresponding quantitative model.