Incomplete Assembly of the Dystrophin-Associated Protein Complex in 2D and 3D-Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Incomplete Assembly of the Dystrophin-Associated Protein Complex in 2D and 3D-Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM) are increasingly used to study genetic diseases on a human background. However, the lack of a fully mature adult cardiomyocyte phenotype of hiPSC-CM may be limiting the scope of these studies. Muscular dystrophies and concomitant...

Full description

Saved in:
Bibliographic Details
Main Authors: Guillaume Gilbert, Chandan Kadur Nagaraju, Robin Duelen, Matthew Amoni, Pierre Bobin, Thomas Eschenhagen, H. Llewelyn Roderick, Maurilio Sampaolesi, Karin R. Sipido
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
dystrophin-associated glycoprotein complex
human induced pluripotent stem cells
hiPSC-derived cardiomyocytes
sarcoglycanopathy
hiPSC cardiomyocyte maturation
Duchenne muscular dystrophy
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/b35c150cb7c84d46b27ae8cd2dd0d249
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/b35c150cb7c84d46b27ae8cd2dd0d249

Similar Items