Incomplete Assembly of the Dystrophin-Associated Protein Complex in 2D and 3D-Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Incomplete Assembly of the Dystrophin-Associated Protein Complex in 2D and 3D-Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM) are increasingly used to study genetic diseases on a human background. However, the lack of a fully mature adult cardiomyocyte phenotype of hiPSC-CM may be limiting the scope of these studies. Muscular dystrophies and concomitant...

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Détails bibliographiques
Auteurs principaux: Guillaume Gilbert, Chandan Kadur Nagaraju, Robin Duelen, Matthew Amoni, Pierre Bobin, Thomas Eschenhagen, H. Llewelyn Roderick, Maurilio Sampaolesi, Karin R. Sipido
Format: article
Langue:EN
Publié: Frontiers Media S.A. 2021
Sujets:
dystrophin-associated glycoprotein complex
human induced pluripotent stem cells
hiPSC-derived cardiomyocytes
sarcoglycanopathy
hiPSC cardiomyocyte maturation
Duchenne muscular dystrophy
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/b35c150cb7c84d46b27ae8cd2dd0d249
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https://doaj.org/article/b35c150cb7c84d46b27ae8cd2dd0d249

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