Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, binding its ligand (ICOS-L) on activated T cells. The structure of the ICOS/ICOS-L complex reveals a distinct receptor binding orientation. The structures of ICOS and ICOS-L in complex with potentially therapeutic antibodies...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Edurne Rujas, Hong Cui, Taylor Sicard, Anthony Semesi, Jean-Philippe Julien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b38ff9a498494347a9468808e58367ab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b38ff9a498494347a9468808e58367ab
record_format	dspace
spelling	oai:doaj.org-article:b38ff9a498494347a9468808e58367ab2021-12-02T19:16:29ZStructural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies10.1038/s41467-020-18828-42041-1723https://doaj.org/article/b38ff9a498494347a9468808e58367ab2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18828-4https://doaj.org/toc/2041-1723The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, binding its ligand (ICOS-L) on activated T cells. The structure of the ICOS/ICOS-L complex reveals a distinct receptor binding orientation. The structures of ICOS and ICOS-L in complex with potentially therapeutic antibodies suggest the structural basis of such antibodies’ efficacies and high binding affinities.Edurne RujasHong CuiTaylor SicardAnthony SemesiJean-Philippe JulienNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edurne Rujas Hong Cui Taylor Sicard Anthony Semesi Jean-Philippe Julien Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies
description	The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, binding its ligand (ICOS-L) on activated T cells. The structure of the ICOS/ICOS-L complex reveals a distinct receptor binding orientation. The structures of ICOS and ICOS-L in complex with potentially therapeutic antibodies suggest the structural basis of such antibodies’ efficacies and high binding affinities.
format	article
author	Edurne Rujas Hong Cui Taylor Sicard Anthony Semesi Jean-Philippe Julien
author_facet	Edurne Rujas Hong Cui Taylor Sicard Anthony Semesi Jean-Philippe Julien
author_sort	Edurne Rujas
title	Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies
title_short	Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies
title_full	Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies
title_fullStr	Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies
title_full_unstemmed	Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies
title_sort	structural characterization of the icos/icos-l immune complex reveals high molecular mimicry by therapeutic antibodies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b38ff9a498494347a9468808e58367ab
work_keys_str_mv	AT edurnerujas structuralcharacterizationoftheicosicoslimmunecomplexrevealshighmolecularmimicrybytherapeuticantibodies AT hongcui structuralcharacterizationoftheicosicoslimmunecomplexrevealshighmolecularmimicrybytherapeuticantibodies AT taylorsicard structuralcharacterizationoftheicosicoslimmunecomplexrevealshighmolecularmimicrybytherapeuticantibodies AT anthonysemesi structuralcharacterizationoftheicosicoslimmunecomplexrevealshighmolecularmimicrybytherapeuticantibodies AT jeanphilippejulien structuralcharacterizationoftheicosicoslimmunecomplexrevealshighmolecularmimicrybytherapeuticantibodies
_version_	1718376932558503936

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

Ejemplares similares