Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

Abstract The nuclear receptor retinoid-related orphan receptor gamma t (RORγt) plays a critical role in driving Th17 cell differentiation and expansion, as well as IL-17 production in innate and adaptive immune cells. The IL-23/IL-17 axis is implicated in several autoimmune and inflammatory diseases...

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Main Authors: Xiaohua Xue, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Glenda Castro, Michael Albers, Freddy Schoetens, Samuel DePrimo, Damayanthi Devineni, Thomas Wilde, Steve Goldberg, Thomas Hoffmann, Anne M. Fourie, Robin L. Thurmond
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/b41726b0e6ed4617b45bd45046be2ee9
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https://doaj.org/article/b41726b0e6ed4617b45bd45046be2ee9

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