Crystal structure of the dengue virus methyltransferase bound to a 5'-capped octameric RNA.
The N-terminal domain of the flavivirus NS5 protein functions as a methyltransferase (MTase). It sequentially methylates the N7 and 2'-O positions of the viral RNA cap structure (GpppA→(7me)GpppA→(7me)GpppA(2'-O-me)). The same NS5 domain could also have a guanylyltransferase activity (GTP+...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Public Library of Science (PLoS)
2010
|
| Subjects: | |
| Online Access: | https://doaj.org/article/b42b0853a571424f90c622a09a1b7d53 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|