Germline de novo mutation rates on exons versus introns in humans

Evidence that somatic mutation rates in introns exceed those in exons challenges the molecular evolution tenet that mutation rate and sequence function are independent. Here, authors analyze germline de novo mutations and reveal no evidence for mutation rate differences between exons and introns.

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Autores principales: Miguel Rodriguez-Galindo, Sònia Casillas, Donate Weghorn, Antonio Barbadilla
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b44853079ea94abfa57b3f57524a795b
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