Germline de novo mutation rates on exons versus introns in humans

Evidence that somatic mutation rates in introns exceed those in exons challenges the molecular evolution tenet that mutation rate and sequence function are independent. Here, authors analyze germline de novo mutations and reveal no evidence for mutation rate differences between exons and introns.

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Autores principales:	Miguel Rodriguez-Galindo, Sònia Casillas, Donate Weghorn, Antonio Barbadilla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b44853079ea94abfa57b3f57524a795b
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spelling	oai:doaj.org-article:b44853079ea94abfa57b3f57524a795b2021-12-02T16:10:52ZGermline de novo mutation rates on exons versus introns in humans10.1038/s41467-020-17162-z2041-1723https://doaj.org/article/b44853079ea94abfa57b3f57524a795b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17162-zhttps://doaj.org/toc/2041-1723Evidence that somatic mutation rates in introns exceed those in exons challenges the molecular evolution tenet that mutation rate and sequence function are independent. Here, authors analyze germline de novo mutations and reveal no evidence for mutation rate differences between exons and introns.Miguel Rodriguez-GalindoSònia CasillasDonate WeghornAntonio BarbadillaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miguel Rodriguez-Galindo Sònia Casillas Donate Weghorn Antonio Barbadilla Germline de novo mutation rates on exons versus introns in humans
description	Evidence that somatic mutation rates in introns exceed those in exons challenges the molecular evolution tenet that mutation rate and sequence function are independent. Here, authors analyze germline de novo mutations and reveal no evidence for mutation rate differences between exons and introns.
format	article
author	Miguel Rodriguez-Galindo Sònia Casillas Donate Weghorn Antonio Barbadilla
author_facet	Miguel Rodriguez-Galindo Sònia Casillas Donate Weghorn Antonio Barbadilla
author_sort	Miguel Rodriguez-Galindo
title	Germline de novo mutation rates on exons versus introns in humans
title_short	Germline de novo mutation rates on exons versus introns in humans
title_full	Germline de novo mutation rates on exons versus introns in humans
title_fullStr	Germline de novo mutation rates on exons versus introns in humans
title_full_unstemmed	Germline de novo mutation rates on exons versus introns in humans
title_sort	germline de novo mutation rates on exons versus introns in humans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b44853079ea94abfa57b3f57524a795b
work_keys_str_mv	AT miguelrodriguezgalindo germlinedenovomutationratesonexonsversusintronsinhumans AT soniacasillas germlinedenovomutationratesonexonsversusintronsinhumans AT donateweghorn germlinedenovomutationratesonexonsversusintronsinhumans AT antoniobarbadilla germlinedenovomutationratesonexonsversusintronsinhumans
_version_	1718384432644096000

Germline de novo mutation rates on exons versus introns in humans

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