Intermolecular steric inhibition of Ephexin4 is relieved by Elmo1

Abstract Ephexin4, a guanine nucleotide-exchange factor for RhoG, promotes engulfment of apoptotic cells and cancer cell migration in a RhoG-dependent manner, which is synergistically augmented by Elmo1, an Ephexin4-interacting protein. However, the underlying molecular mechanism remains elusive. He...

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Autores principales: Kwanhyeong Kim, Juyeon Lee, Sang-Ah Lee, Hyunji Moon, Boyeon Park, Deokhwan Kim, Young-Eun Joo, Daeho Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b45c903de0bc48c98bb1fcbc24f70091
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