Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during <named-content content-type="genus-species">Clostridium difficile</named-content> Infections

ABSTRACT Clostridium difficile is a leading cause of antibiotic-associated diarrhea, a significant animal pathogen, and a worldwide public health burden. Most disease-causing strains secrete two exotoxins, TcdA and TcdB, which are considered to be the primary virulence factors. Understanding the rol...

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Auteurs principaux:	Glen P. Carter, Anjana Chakravorty, Tu Anh Pham Nguyen, Steven Mileto, Fernanda Schreiber, Lucy Li, Pauline Howarth, Simon Clare, Bliss Cunningham, Susan P. Sambol, Adam Cheknis, Iris Figueroa, Stuart Johnson, Dale Gerding, Julian I. Rood, Gordon Dougan, Trevor D. Lawley, Dena Lyras
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2015
Sujets:	Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/b47764f906484de9a05ec4ef6bf39866
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Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during <named-content content-type="genus-species">Clostridium difficile</named-content> Infections

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