Unraveling cardiolipin-induced conformational change of cytochrome c through H/D exchange mass spectrometry and quartz crystal microbalance

Abstract Cardiolipin (CL), a crucial component in inner mitochondrial membranes, interacts with cytochrome c (cyt c) to form a peroxidase complex for the catalysis of CL oxidation. Such interaction is pivotal to the mitochondrial regulation of apoptosis and is affected by the redox state of cyt c. I...

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Autores principales: Sin-Cih Sun, Hung-Wei Huang, Yi-Ting Lo, Min-Chieh Chuang, Yuan-Hao Howard Hsu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b47cb996b48543e1aa76fc35c5f1f34e
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