Aromatic thiol-mediated cleavage of N–O bonds enables chemical ubiquitylation of folded proteins
Chemical approaches to site-specifically ubiquitylate a target protein allow investigation of the biochemical effects of this modification, but they often destabilize the protein. Here, the authors report on a synthetic conjugation strategy that leads to protein ubiquitylation in non-denaturing cond...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2016
|
| Subjects: | |
| Online Access: | https://doaj.org/article/b48cef68f3dc4e9fa4b70b0add885ae3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|