Pharmacological AMP kinase activators target the nucleolar organization and control cell proliferation.

<h4>Aims</h4>Phenformin, resveratrol and AICAR stimulate the energy sensor 5'-AMP activated kinase (AMPK) and inhibit the first step of ribosome biogenesis, de novo RNA synthesis in nucleoli. Nucleolar activities are relevant to human health, because ribosome production is crucial t...

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Autores principales: Mohamed Kodiha, Ali Salimi, Yi Meng Wang, Ursula Stochaj
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/b4b332cd9f614f51b36f39a9361bff20
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