Bone protection by inhibition of microRNA-182

Osteoclasts mediate bone disruption in a number of degenerative bone diseases. Here, the authors show that miR-182 regulates osteoclastogenesis via PKR and IFN-beta signaling, is correlated with rheumatoid arthritis, and that its ablation or inhibition is protective against bone erosion in mouse mod...

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Autores principales: Kazuki Inoue, Zhonghao Deng, Yufan Chen, Eugenia Giannopoulou, Ren Xu, Shiaoching Gong, Matthew B. Greenblatt, Lingegowda S. Mangala, Gabriel Lopez-Berestein, David G. Kirsch, Anil K. Sood, Liang Zhao, Baohong Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b4b9145ef0434abfa54670e362c640db
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