Bone protection by inhibition of microRNA-182

Bone protection by inhibition of microRNA-182

Osteoclasts mediate bone disruption in a number of degenerative bone diseases. Here, the authors show that miR-182 regulates osteoclastogenesis via PKR and IFN-beta signaling, is correlated with rheumatoid arthritis, and that its ablation or inhibition is protective against bone erosion in mouse mod...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kazuki Inoue, Zhonghao Deng, Yufan Chen, Eugenia Giannopoulou, Ren Xu, Shiaoching Gong, Matthew B. Greenblatt, Lingegowda S. Mangala, Gabriel Lopez-Berestein, David G. Kirsch, Anil K. Sood, Liang Zhao, Baohong Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/b4b9145ef0434abfa54670e362c640db
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:b4b9145ef0434abfa54670e362c640db
record_format dspace
spelling oai:doaj.org-article:b4b9145ef0434abfa54670e362c640db2021-12-02T15:34:40ZBone protection by inhibition of microRNA-18210.1038/s41467-018-06446-02041-1723https://doaj.org/article/b4b9145ef0434abfa54670e362c640db2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06446-0https://doaj.org/toc/2041-1723Osteoclasts mediate bone disruption in a number of degenerative bone diseases. Here, the authors show that miR-182 regulates osteoclastogenesis via PKR and IFN-beta signaling, is correlated with rheumatoid arthritis, and that its ablation or inhibition is protective against bone erosion in mouse models of osteoporosis or inflammatory arthritis.Kazuki InoueZhonghao DengYufan ChenEugenia GiannopoulouRen XuShiaoching GongMatthew B. GreenblattLingegowda S. MangalaGabriel Lopez-BeresteinDavid G. KirschAnil K. SoodLiang ZhaoBaohong ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kazuki Inoue
Zhonghao Deng
Yufan Chen
Eugenia Giannopoulou
Ren Xu
Shiaoching Gong
Matthew B. Greenblatt
Lingegowda S. Mangala
Gabriel Lopez-Berestein
David G. Kirsch
Anil K. Sood
Liang Zhao
Baohong Zhao
Bone protection by inhibition of microRNA-182
description Osteoclasts mediate bone disruption in a number of degenerative bone diseases. Here, the authors show that miR-182 regulates osteoclastogenesis via PKR and IFN-beta signaling, is correlated with rheumatoid arthritis, and that its ablation or inhibition is protective against bone erosion in mouse models of osteoporosis or inflammatory arthritis.
format article
author Kazuki Inoue
Zhonghao Deng
Yufan Chen
Eugenia Giannopoulou
Ren Xu
Shiaoching Gong
Matthew B. Greenblatt
Lingegowda S. Mangala
Gabriel Lopez-Berestein
David G. Kirsch
Anil K. Sood
Liang Zhao
Baohong Zhao
author_facet Kazuki Inoue
Zhonghao Deng
Yufan Chen
Eugenia Giannopoulou
Ren Xu
Shiaoching Gong
Matthew B. Greenblatt
Lingegowda S. Mangala
Gabriel Lopez-Berestein
David G. Kirsch
Anil K. Sood
Liang Zhao
Baohong Zhao
author_sort Kazuki Inoue
title Bone protection by inhibition of microRNA-182
title_short Bone protection by inhibition of microRNA-182
title_full Bone protection by inhibition of microRNA-182
title_fullStr Bone protection by inhibition of microRNA-182
title_full_unstemmed Bone protection by inhibition of microRNA-182
title_sort bone protection by inhibition of microrna-182
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/b4b9145ef0434abfa54670e362c640db
work_keys_str_mv AT kazukiinoue boneprotectionbyinhibitionofmicrorna182
AT zhonghaodeng boneprotectionbyinhibitionofmicrorna182
AT yufanchen boneprotectionbyinhibitionofmicrorna182
AT eugeniagiannopoulou boneprotectionbyinhibitionofmicrorna182
AT renxu boneprotectionbyinhibitionofmicrorna182
AT shiaochinggong boneprotectionbyinhibitionofmicrorna182
AT matthewbgreenblatt boneprotectionbyinhibitionofmicrorna182
AT lingegowdasmangala boneprotectionbyinhibitionofmicrorna182
AT gabriellopezberestein boneprotectionbyinhibitionofmicrorna182
AT davidgkirsch boneprotectionbyinhibitionofmicrorna182
AT anilksood boneprotectionbyinhibitionofmicrorna182
AT liangzhao boneprotectionbyinhibitionofmicrorna182
AT baohongzhao boneprotectionbyinhibitionofmicrorna182
_version_ 1718386800769105920

Ejemplares similares