Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.

The iminosugar N-(5'-adamantane-1'-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of glycosphingolipid (GSL) biosynthesis is known to ameliorate diabetes, insulin sensitivity and to prevent liver steatosis in ob/ob mice. Thus far the effect of GSL synthesis inhibition on pr...

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Auteurs principaux: Elisa Lombardo, Cindy P A A van Roomen, Gijs H van Puijvelde, Roelof Ottenhoff, Marco van Eijk, Jan Aten, Johan Kuiper, Herman S Overkleeft, Albert K Groen, Arthur J Verhoeven, Johannes M F G Aerts, Florence Bietrix
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/b4de28f60b924b2b844fb54d2c4ccfb1
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https://doaj.org/article/b4de28f60b924b2b844fb54d2c4ccfb1

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