Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.

To determine the spatial and temporal dynamics of influenza A virus during a single epidemic, we examined whole-genome sequences of 284 A/H1N1 and 69 A/H3N2 viruses collected across the continental United States during the 2006-2007 influenza season, representing the largest study of its kind undert...

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Autores principales:	Martha I Nelson, Laurel Edelman, David J Spiro, Alex R Boyne, Jayati Bera, Rebecca Halpin, Naomi Sengamalay, Elodie Ghedin, Mark A Miller, Lone Simonsen, Cecile Viboud, Edward C Holmes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b4e23f550f5648bead16610fd5a7eac1
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spelling	oai:doaj.org-article:b4e23f550f5648bead16610fd5a7eac12021-11-25T05:47:31ZMolecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.1553-73661553-737410.1371/journal.ppat.1000133https://doaj.org/article/b4e23f550f5648bead16610fd5a7eac12008-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18725925/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374To determine the spatial and temporal dynamics of influenza A virus during a single epidemic, we examined whole-genome sequences of 284 A/H1N1 and 69 A/H3N2 viruses collected across the continental United States during the 2006-2007 influenza season, representing the largest study of its kind undertaken to date. A phylogenetic analysis revealed that multiple clades of both A/H1N1 and A/H3N2 entered and co-circulated in the United States during this season, even in localities that are distant from major metropolitan areas, and with no clear pattern of spatial spread. In addition, co-circulating clades of the same subtype exchanged genome segments through reassortment, producing both a minor clade of A/H3N2 viruses that appears to have re-acquired sensitivity to the adamantane class of antiviral drugs, as well as a likely antigenically distinct A/H1N1 clade that became globally dominant following this season. Overall, the co-circulation of multiple viral clades during the 2006-2007 epidemic season revealed patterns of spatial spread that are far more complex than observed previously, and suggests a major role for both migration and reassortment in shaping the epidemiological dynamics of human influenza A virus.Martha I NelsonLaurel EdelmanDavid J SpiroAlex R BoyneJayati BeraRebecca HalpinNaomi SengamalayElodie GhedinMark A MillerLone SimonsenCecile ViboudEdward C HolmesPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 8, p e1000133 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Martha I Nelson Laurel Edelman David J Spiro Alex R Boyne Jayati Bera Rebecca Halpin Naomi Sengamalay Elodie Ghedin Mark A Miller Lone Simonsen Cecile Viboud Edward C Holmes Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.
description	To determine the spatial and temporal dynamics of influenza A virus during a single epidemic, we examined whole-genome sequences of 284 A/H1N1 and 69 A/H3N2 viruses collected across the continental United States during the 2006-2007 influenza season, representing the largest study of its kind undertaken to date. A phylogenetic analysis revealed that multiple clades of both A/H1N1 and A/H3N2 entered and co-circulated in the United States during this season, even in localities that are distant from major metropolitan areas, and with no clear pattern of spatial spread. In addition, co-circulating clades of the same subtype exchanged genome segments through reassortment, producing both a minor clade of A/H3N2 viruses that appears to have re-acquired sensitivity to the adamantane class of antiviral drugs, as well as a likely antigenically distinct A/H1N1 clade that became globally dominant following this season. Overall, the co-circulation of multiple viral clades during the 2006-2007 epidemic season revealed patterns of spatial spread that are far more complex than observed previously, and suggests a major role for both migration and reassortment in shaping the epidemiological dynamics of human influenza A virus.
format	article
author	Martha I Nelson Laurel Edelman David J Spiro Alex R Boyne Jayati Bera Rebecca Halpin Naomi Sengamalay Elodie Ghedin Mark A Miller Lone Simonsen Cecile Viboud Edward C Holmes
author_facet	Martha I Nelson Laurel Edelman David J Spiro Alex R Boyne Jayati Bera Rebecca Halpin Naomi Sengamalay Elodie Ghedin Mark A Miller Lone Simonsen Cecile Viboud Edward C Holmes
author_sort	Martha I Nelson
title	Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.
title_short	Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.
title_full	Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.
title_fullStr	Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.
title_full_unstemmed	Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.
title_sort	molecular epidemiology of a/h3n2 and a/h1n1 influenza virus during a single epidemic season in the united states.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/b4e23f550f5648bead16610fd5a7eac1
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Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.

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