Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis
Upon starvation, cells coordinate protein disposal to recycle amino acids, although the role of the proteasome has been unclear. Here, the authors show that in the mammalian nucleus, proteasomes form condensates that dissolve following nutrient replenishment.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b50e1f83646949fdb482fa1c4a35c9f5 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b50e1f83646949fdb482fa1c4a35c9f5 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b50e1f83646949fdb482fa1c4a35c9f52021-12-05T12:22:18ZStarvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis10.1038/s41467-021-27306-42041-1723https://doaj.org/article/b50e1f83646949fdb482fa1c4a35c9f52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27306-4https://doaj.org/toc/2041-1723Upon starvation, cells coordinate protein disposal to recycle amino acids, although the role of the proteasome has been unclear. Here, the authors show that in the mammalian nucleus, proteasomes form condensates that dissolve following nutrient replenishment.Maxime UriarteNadine Sen NkweRoch TremblayOumaima AhmedClémence MessmerNazar MashtalirHaithem BarbourLouis MasclefMarion VoideClaire ViallardSalima DaouDjaileb AbdelhadiDaryl RonatoMohammadjavad PaydarAnaïs DarracqKarine BoulayNicolas Desjardins-LecavalierPrzemyslaw SapiehaJean-Yves MassonMikhail SergeevBenjamin H. KwokLaura HuleaFrédérick A. MalletteEric MilotBruno LarrivéeHugo WurteleEl Bachir AffarNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Maxime Uriarte Nadine Sen Nkwe Roch Tremblay Oumaima Ahmed Clémence Messmer Nazar Mashtalir Haithem Barbour Louis Masclef Marion Voide Claire Viallard Salima Daou Djaileb Abdelhadi Daryl Ronato Mohammadjavad Paydar Anaïs Darracq Karine Boulay Nicolas Desjardins-Lecavalier Przemyslaw Sapieha Jean-Yves Masson Mikhail Sergeev Benjamin H. Kwok Laura Hulea Frédérick A. Mallette Eric Milot Bruno Larrivée Hugo Wurtele El Bachir Affar Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis |
| description |
Upon starvation, cells coordinate protein disposal to recycle amino acids, although the role of the proteasome has been unclear. Here, the authors show that in the mammalian nucleus, proteasomes form condensates that dissolve following nutrient replenishment. |
| format |
article |
| author |
Maxime Uriarte Nadine Sen Nkwe Roch Tremblay Oumaima Ahmed Clémence Messmer Nazar Mashtalir Haithem Barbour Louis Masclef Marion Voide Claire Viallard Salima Daou Djaileb Abdelhadi Daryl Ronato Mohammadjavad Paydar Anaïs Darracq Karine Boulay Nicolas Desjardins-Lecavalier Przemyslaw Sapieha Jean-Yves Masson Mikhail Sergeev Benjamin H. Kwok Laura Hulea Frédérick A. Mallette Eric Milot Bruno Larrivée Hugo Wurtele El Bachir Affar |
| author_facet |
Maxime Uriarte Nadine Sen Nkwe Roch Tremblay Oumaima Ahmed Clémence Messmer Nazar Mashtalir Haithem Barbour Louis Masclef Marion Voide Claire Viallard Salima Daou Djaileb Abdelhadi Daryl Ronato Mohammadjavad Paydar Anaïs Darracq Karine Boulay Nicolas Desjardins-Lecavalier Przemyslaw Sapieha Jean-Yves Masson Mikhail Sergeev Benjamin H. Kwok Laura Hulea Frédérick A. Mallette Eric Milot Bruno Larrivée Hugo Wurtele El Bachir Affar |
| author_sort |
Maxime Uriarte |
| title |
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis |
| title_short |
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis |
| title_full |
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis |
| title_fullStr |
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis |
| title_full_unstemmed |
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis |
| title_sort |
starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b50e1f83646949fdb482fa1c4a35c9f5 |
| work_keys_str_mv |
AT maximeuriarte starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT nadinesennkwe starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT rochtremblay starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT oumaimaahmed starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT clemencemessmer starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT nazarmashtalir starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT haithembarbour starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT louismasclef starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT marionvoide starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT claireviallard starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT salimadaou starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT djailebabdelhadi starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT darylronato starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT mohammadjavadpaydar starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT anaisdarracq starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT karineboulay starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT nicolasdesjardinslecavalier starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT przemyslawsapieha starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT jeanyvesmasson starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT mikhailsergeev starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT benjaminhkwok starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT laurahulea starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT frederickamallette starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT ericmilot starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT brunolarrivee starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT hugowurtele starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis AT elbachiraffar starvationinducedproteasomeassembliesinthenucleuslinkaminoacidsupplytoapoptosis |
| _version_ |
1718372035459022848 |