Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows Repressor Element of Parkin removal, E3 ligase acti...

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Autores principales: Matthew Y. Tang, Marta Vranas, Andrea I. Krahn, Shayal Pundlik, Jean- François Trempe, Edward A. Fon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b55f87d3a9934780bd5addb22763e47c
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