Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows Repressor Element of Parkin removal, E3 ligase acti...

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Autores principales:	Matthew Y. Tang, Marta Vranas, Andrea I. Krahn, Shayal Pundlik, Jean- François Trempe, Edward A. Fon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b55f87d3a9934780bd5addb22763e47c
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id	oai:doaj.org-article:b55f87d3a9934780bd5addb22763e47c
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spelling	oai:doaj.org-article:b55f87d3a9934780bd5addb22763e47c2021-12-02T15:38:53ZStructure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation10.1038/ncomms146972041-1723https://doaj.org/article/b55f87d3a9934780bd5addb22763e47c2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14697https://doaj.org/toc/2041-1723Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows Repressor Element of Parkin removal, E3 ligase activation and mitophagy.Matthew Y. TangMarta VranasAndrea I. KrahnShayal PundlikJean- François TrempeEdward A. FonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew Y. Tang Marta Vranas Andrea I. Krahn Shayal Pundlik Jean- François Trempe Edward A. Fon Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
description	Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows Repressor Element of Parkin removal, E3 ligase activation and mitophagy.
format	article
author	Matthew Y. Tang Marta Vranas Andrea I. Krahn Shayal Pundlik Jean- François Trempe Edward A. Fon
author_facet	Matthew Y. Tang Marta Vranas Andrea I. Krahn Shayal Pundlik Jean- François Trempe Edward A. Fon
author_sort	Matthew Y. Tang
title	Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_short	Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_full	Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_fullStr	Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_full_unstemmed	Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation
title_sort	structure-guided mutagenesis reveals a hierarchical mechanism of parkin activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b55f87d3a9934780bd5addb22763e47c
work_keys_str_mv	AT matthewytang structureguidedmutagenesisrevealsahierarchicalmechanismofparkinactivation AT martavranas structureguidedmutagenesisrevealsahierarchicalmechanismofparkinactivation AT andreaikrahn structureguidedmutagenesisrevealsahierarchicalmechanismofparkinactivation AT shayalpundlik structureguidedmutagenesisrevealsahierarchicalmechanismofparkinactivation AT jeanfrancoistrempe structureguidedmutagenesisrevealsahierarchicalmechanismofparkinactivation AT edwardafon structureguidedmutagenesisrevealsahierarchicalmechanismofparkinactivation
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Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

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