Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

The relative contribution of fallopian tube (FT) or ovarian surface epithelium (OSE) to high-grade serous ovarian cancer (HG-SOC) development is unclear. Here, the authors establish organoid models from murine oviductal and OSE tissues that allow cancer modeling via CRISPR-Cas9 genome editing, and r...

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Autores principales:	Kadi Lõhmussaar, Oded Kopper, Jeroen Korving, Harry Begthel, Celien P. H. Vreuls, Johan H. van Es, Hans Clevers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b561dc387d334f75b89e8a94ccc8b593
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id	oai:doaj.org-article:b561dc387d334f75b89e8a94ccc8b593
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spelling	oai:doaj.org-article:b561dc387d334f75b89e8a94ccc8b5932021-12-02T15:49:49ZAssessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids10.1038/s41467-020-16432-02041-1723https://doaj.org/article/b561dc387d334f75b89e8a94ccc8b5932020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16432-0https://doaj.org/toc/2041-1723The relative contribution of fallopian tube (FT) or ovarian surface epithelium (OSE) to high-grade serous ovarian cancer (HG-SOC) development is unclear. Here, the authors establish organoid models from murine oviductal and OSE tissues that allow cancer modeling via CRISPR-Cas9 genome editing, and report a dual origin of murine HG-SOC.Kadi LõhmussaarOded KopperJeroen KorvingHarry BegthelCelien P. H. VreulsJohan H. van EsHans CleversNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kadi Lõhmussaar Oded Kopper Jeroen Korving Harry Begthel Celien P. H. Vreuls Johan H. van Es Hans Clevers Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
description	The relative contribution of fallopian tube (FT) or ovarian surface epithelium (OSE) to high-grade serous ovarian cancer (HG-SOC) development is unclear. Here, the authors establish organoid models from murine oviductal and OSE tissues that allow cancer modeling via CRISPR-Cas9 genome editing, and report a dual origin of murine HG-SOC.
format	article
author	Kadi Lõhmussaar Oded Kopper Jeroen Korving Harry Begthel Celien P. H. Vreuls Johan H. van Es Hans Clevers
author_facet	Kadi Lõhmussaar Oded Kopper Jeroen Korving Harry Begthel Celien P. H. Vreuls Johan H. van Es Hans Clevers
author_sort	Kadi Lõhmussaar
title	Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
title_short	Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
title_full	Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
title_fullStr	Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
title_full_unstemmed	Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids
title_sort	assessing the origin of high-grade serous ovarian cancer using crispr-modification of mouse organoids
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b561dc387d334f75b89e8a94ccc8b593
work_keys_str_mv	AT kadilohmussaar assessingtheoriginofhighgradeserousovariancancerusingcrisprmodificationofmouseorganoids AT odedkopper assessingtheoriginofhighgradeserousovariancancerusingcrisprmodificationofmouseorganoids AT jeroenkorving assessingtheoriginofhighgradeserousovariancancerusingcrisprmodificationofmouseorganoids AT harrybegthel assessingtheoriginofhighgradeserousovariancancerusingcrisprmodificationofmouseorganoids AT celienphvreuls assessingtheoriginofhighgradeserousovariancancerusingcrisprmodificationofmouseorganoids AT johanhvanes assessingtheoriginofhighgradeserousovariancancerusingcrisprmodificationofmouseorganoids AT hansclevers assessingtheoriginofhighgradeserousovariancancerusingcrisprmodificationofmouseorganoids
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Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

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