Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

The relative contribution of fallopian tube (FT) or ovarian surface epithelium (OSE) to high-grade serous ovarian cancer (HG-SOC) development is unclear. Here, the authors establish organoid models from murine oviductal and OSE tissues that allow cancer modeling via CRISPR-Cas9 genome editing, and r...

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Autores principales: Kadi Lõhmussaar, Oded Kopper, Jeroen Korving, Harry Begthel, Celien P. H. Vreuls, Johan H. van Es, Hans Clevers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/b561dc387d334f75b89e8a94ccc8b593
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