Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers

Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers

Neoantigen load has been associated with tumour immune infiltration. Here, the authors show that while this is true for tumours with recurrent mutations, cancers with recurrent CNAs show neoantigen-independent infiltration driven by cytokine production downstream of the DNA damage sensor ATM.

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Autores principales: Daniel J. McGrail, Lorenzo Federico, Yongsheng Li, Hui Dai, Yiling Lu, Gordon B. Mills, Song Yi, Shiaw-Yih Lin, Nidhi Sahni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b562f0fd3728439aa82b66de17639985
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spelling oai:doaj.org-article:b562f0fd3728439aa82b66de176399852021-12-02T17:32:01ZMulti-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers10.1038/s41467-018-03730-x2041-1723https://doaj.org/article/b562f0fd3728439aa82b66de176399852018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03730-xhttps://doaj.org/toc/2041-1723Neoantigen load has been associated with tumour immune infiltration. Here, the authors show that while this is true for tumours with recurrent mutations, cancers with recurrent CNAs show neoantigen-independent infiltration driven by cytokine production downstream of the DNA damage sensor ATM.Daniel J. McGrailLorenzo FedericoYongsheng LiHui DaiYiling LuGordon B. MillsSong YiShiaw-Yih LinNidhi SahniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Daniel J. McGrail
Lorenzo Federico
Yongsheng Li
Hui Dai
Yiling Lu
Gordon B. Mills
Song Yi
Shiaw-Yih Lin
Nidhi Sahni
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
description Neoantigen load has been associated with tumour immune infiltration. Here, the authors show that while this is true for tumours with recurrent mutations, cancers with recurrent CNAs show neoantigen-independent infiltration driven by cytokine production downstream of the DNA damage sensor ATM.
format article
author Daniel J. McGrail
Lorenzo Federico
Yongsheng Li
Hui Dai
Yiling Lu
Gordon B. Mills
Song Yi
Shiaw-Yih Lin
Nidhi Sahni
author_facet Daniel J. McGrail
Lorenzo Federico
Yongsheng Li
Hui Dai
Yiling Lu
Gordon B. Mills
Song Yi
Shiaw-Yih Lin
Nidhi Sahni
author_sort Daniel J. McGrail
title Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
title_short Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
title_full Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
title_fullStr Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
title_full_unstemmed Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
title_sort multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/b562f0fd3728439aa82b66de17639985
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AT lorenzofederico multiomicsanalysisrevealsneoantigenindependentimmunecellinfiltrationincopynumberdrivencancers
AT yongshengli multiomicsanalysisrevealsneoantigenindependentimmunecellinfiltrationincopynumberdrivencancers
AT huidai multiomicsanalysisrevealsneoantigenindependentimmunecellinfiltrationincopynumberdrivencancers
AT yilinglu multiomicsanalysisrevealsneoantigenindependentimmunecellinfiltrationincopynumberdrivencancers
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AT songyi multiomicsanalysisrevealsneoantigenindependentimmunecellinfiltrationincopynumberdrivencancers
AT shiawyihlin multiomicsanalysisrevealsneoantigenindependentimmunecellinfiltrationincopynumberdrivencancers
AT nidhisahni multiomicsanalysisrevealsneoantigenindependentimmunecellinfiltrationincopynumberdrivencancers
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