Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers

Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers

Neoantigen load has been associated with tumour immune infiltration. Here, the authors show that while this is true for tumours with recurrent mutations, cancers with recurrent CNAs show neoantigen-independent infiltration driven by cytokine production downstream of the DNA damage sensor ATM.

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Detalles Bibliográficos
Autores principales: Daniel J. McGrail, Lorenzo Federico, Yongsheng Li, Hui Dai, Yiling Lu, Gordon B. Mills, Song Yi, Shiaw-Yih Lin, Nidhi Sahni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/b562f0fd3728439aa82b66de17639985
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