IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors

Abstract Background Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is regulated in metastatic microenvironment caused by colorectal cancer is...

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Autores principales: Qian Jin, He Yang, Zhao Jing, Wu Hong-hua, Song Ben-jing, Wang Li-ting, Ye Li-juan, Xu Wei, Kang Xia, Wu Juan, Zheng Wei
Formato: article
Lenguaje:EN
Publicado: BMC 2021
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CRC
Acceso en línea:https://doaj.org/article/b5705a35020149179e6f97d2887d6a94
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