Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer

Triptolide (TPL) is a small molecule isolated from a traditional Chinese herb Tripterygium wilfordii Hook F and shows excellent anticancer effect for pancreatic cancer cells. However, the poor water solubility ad severe liver toxicity of TPL hindered its clinical application. Herein, TPL is covalent...

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Autores principales: Binglin Sui, Chen Cheng, Shanshan Shi, Mingming Wang, Peisheng Xu
Formato: article
Lenguaje:EN
Publicado: Wiley-VCH 2021
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Acceso en línea:https://doaj.org/article/b575ab66e38541609a17951601968fce
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