Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer

Triptolide (TPL) is a small molecule isolated from a traditional Chinese herb Tripterygium wilfordii Hook F and shows excellent anticancer effect for pancreatic cancer cells. However, the poor water solubility ad severe liver toxicity of TPL hindered its clinical application. Herein, TPL is covalent...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Binglin Sui, Chen Cheng, Shanshan Shi, Mingming Wang, Peisheng Xu
Formato:	article
Lenguaje:	EN
Publicado:	Wiley-VCH 2021
Materias:	esterase-activatable intracellular releases nano-prodrug pancreatic cancer triptolide Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/b575ab66e38541609a17951601968fce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b575ab66e38541609a17951601968fce
record_format	dspace
spelling	oai:doaj.org-article:b575ab66e38541609a17951601968fce2021-11-06T04:12:26ZEsterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer2699-930710.1002/anbr.202100040https://doaj.org/article/b575ab66e38541609a17951601968fce2021-11-01T00:00:00Zhttps://doi.org/10.1002/anbr.202100040https://doaj.org/toc/2699-9307Triptolide (TPL) is a small molecule isolated from a traditional Chinese herb Tripterygium wilfordii Hook F and shows excellent anticancer effect for pancreatic cancer cells. However, the poor water solubility ad severe liver toxicity of TPL hindered its clinical application. Herein, TPL is covalently conjugated to a polymer and entrapped inside the core of the TPL nanogel (nTPL) to protect it from premature leakage during blood circulation. With the help of lactobionic acid (LBA), nTPL‐LBA could selectively target the tumors in an orthotopic pancreatic cancer mouse model. TPL could be subsequently released intracellularly in its original form due to the presence of elevated intracellular esterase and GSH, and eventually kills cancer cells. nTPL‐LBA treatment reduces tumor burden by 99% while not introducing TPL‐associated liver and kidney toxicities. Most importantly, more than half of the nTPL‐LBA‐treated animals are tumor‐free, suggesting that nTPL‐LBA is an effective approach in eradicating pancreatic cancer.Binglin SuiChen ChengShanshan ShiMingming WangPeisheng XuWiley-VCHarticleesterase-activatableintracellular releasesnano-prodrugpancreatic cancertriptolideBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENAdvanced NanoBiomed Research, Vol 1, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	esterase-activatable intracellular releases nano-prodrug pancreatic cancer triptolide Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	esterase-activatable intracellular releases nano-prodrug pancreatic cancer triptolide Biotechnology TP248.13-248.65 Medical technology R855-855.5 Binglin Sui Chen Cheng Shanshan Shi Mingming Wang Peisheng Xu Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer
description	Triptolide (TPL) is a small molecule isolated from a traditional Chinese herb Tripterygium wilfordii Hook F and shows excellent anticancer effect for pancreatic cancer cells. However, the poor water solubility ad severe liver toxicity of TPL hindered its clinical application. Herein, TPL is covalently conjugated to a polymer and entrapped inside the core of the TPL nanogel (nTPL) to protect it from premature leakage during blood circulation. With the help of lactobionic acid (LBA), nTPL‐LBA could selectively target the tumors in an orthotopic pancreatic cancer mouse model. TPL could be subsequently released intracellularly in its original form due to the presence of elevated intracellular esterase and GSH, and eventually kills cancer cells. nTPL‐LBA treatment reduces tumor burden by 99% while not introducing TPL‐associated liver and kidney toxicities. Most importantly, more than half of the nTPL‐LBA‐treated animals are tumor‐free, suggesting that nTPL‐LBA is an effective approach in eradicating pancreatic cancer.
format	article
author	Binglin Sui Chen Cheng Shanshan Shi Mingming Wang Peisheng Xu
author_facet	Binglin Sui Chen Cheng Shanshan Shi Mingming Wang Peisheng Xu
author_sort	Binglin Sui
title	Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer
title_short	Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer
title_full	Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer
title_fullStr	Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer
title_full_unstemmed	Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer
title_sort	esterase‐activatable and glutathione‐responsive triptolide nano‐prodrug for the eradication of pancreatic cancer
publisher	Wiley-VCH
publishDate	2021
url	https://doaj.org/article/b575ab66e38541609a17951601968fce
work_keys_str_mv	AT binglinsui esteraseactivatableandglutathioneresponsivetriptolidenanoprodrugfortheeradicationofpancreaticcancer AT chencheng esteraseactivatableandglutathioneresponsivetriptolidenanoprodrugfortheeradicationofpancreaticcancer AT shanshanshi esteraseactivatableandglutathioneresponsivetriptolidenanoprodrugfortheeradicationofpancreaticcancer AT mingmingwang esteraseactivatableandglutathioneresponsivetriptolidenanoprodrugfortheeradicationofpancreaticcancer AT peishengxu esteraseactivatableandglutathioneresponsivetriptolidenanoprodrugfortheeradicationofpancreaticcancer
_version_	1718443937479262208

Esterase‐Activatable and Glutathione‐Responsive Triptolide Nano‐Prodrug for the Eradication of Pancreatic Cancer

Ejemplares similares