Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum

Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum

Dopamine tightly regulates plasticity at corticostriatal synapses. Here, the authors report that endocannabinoid dependent LTP induced with few spikes in the striatum is impaired in a rodent model of Parkinson’s disease, requires dopamine through presynaptic D2 receptors located on corticostriatal i...

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Bibliographic Details
Main Authors: Hao Xu, Sylvie Perez, Amandine Cornil, Bérangère Detraux, Ilya Prokin, Yihui Cui, Bertrand Degos, Hugues Berry, Alban de Kerchove d’Exaerde, Laurent Venance
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/b584366768e1403282f7684c1c3a189a
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https://doaj.org/article/b584366768e1403282f7684c1c3a189a

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