Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum

Dopamine tightly regulates plasticity at corticostriatal synapses. Here, the authors report that endocannabinoid dependent LTP induced with few spikes in the striatum is impaired in a rodent model of Parkinson’s disease, requires dopamine through presynaptic D2 receptors located on corticostriatal i...

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Autores principales:	Hao Xu, Sylvie Perez, Amandine Cornil, Bérangère Detraux, Ilya Prokin, Yihui Cui, Bertrand Degos, Hugues Berry, Alban de Kerchove d’Exaerde, Laurent Venance
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b584366768e1403282f7684c1c3a189a
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spelling	oai:doaj.org-article:b584366768e1403282f7684c1c3a189a2021-12-02T14:39:08ZDopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum10.1038/s41467-018-06409-52041-1723https://doaj.org/article/b584366768e1403282f7684c1c3a189a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06409-5https://doaj.org/toc/2041-1723Dopamine tightly regulates plasticity at corticostriatal synapses. Here, the authors report that endocannabinoid dependent LTP induced with few spikes in the striatum is impaired in a rodent model of Parkinson’s disease, requires dopamine through presynaptic D2 receptors located on corticostriatal inputs.Hao XuSylvie PerezAmandine CornilBérangère DetrauxIlya ProkinYihui CuiBertrand DegosHugues BerryAlban de Kerchove d’ExaerdeLaurent VenanceNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Xu Sylvie Perez Amandine Cornil Bérangère Detraux Ilya Prokin Yihui Cui Bertrand Degos Hugues Berry Alban de Kerchove d’Exaerde Laurent Venance Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
description	Dopamine tightly regulates plasticity at corticostriatal synapses. Here, the authors report that endocannabinoid dependent LTP induced with few spikes in the striatum is impaired in a rodent model of Parkinson’s disease, requires dopamine through presynaptic D2 receptors located on corticostriatal inputs.
format	article
author	Hao Xu Sylvie Perez Amandine Cornil Bérangère Detraux Ilya Prokin Yihui Cui Bertrand Degos Hugues Berry Alban de Kerchove d’Exaerde Laurent Venance
author_facet	Hao Xu Sylvie Perez Amandine Cornil Bérangère Detraux Ilya Prokin Yihui Cui Bertrand Degos Hugues Berry Alban de Kerchove d’Exaerde Laurent Venance
author_sort	Hao Xu
title	Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
title_short	Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
title_full	Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
title_fullStr	Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
title_full_unstemmed	Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
title_sort	dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b584366768e1403282f7684c1c3a189a
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Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum

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