Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids

Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids

Abstract Current treatment options against hepatitis B and D virus (HBV/HDV) infections have only limited curative effects. Identification of Na+/taurocholate co-transporting polypeptide (NTCP) as the high-affinity hepatic receptor for both viruses in 2012 enables target-based development of HBV/HDV...

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Auteurs principaux: Michael Kirstgen, Kira Alessandra Alicia Theresa Lowjaga, Simon Franz Müller, Nora Goldmann, Felix Lehmann, Sami Alakurtti, Jari Yli-Kauhaluoma, Dieter Glebe, Joachim Geyer
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/b5edf866c0b64b18948a6735dc0b00e5
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https://doaj.org/article/b5edf866c0b64b18948a6735dc0b00e5

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