SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression

SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression

Abstract Atypical Teratoid Rhabdoid Tumor (AT/RT) is a rare pediatric central nervous system cancer often characterized by deletion or mutation of SMARCB1, a tumor suppressor gene. In this study, we found that SMARCB1 regulates Human Endogenous Retrovirus K (HERV-K, subtype HML-2) expression. HML-2...

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Auteurs principaux: Tara T. Doucet-O’Hare, Brianna L. DiSanza, Catherine DeMarino, Abigail L. Atkinson, Jared S. Rosenblum, Lisa J. Henderson, Kory R. Johnson, Jeffrey Kowalak, Marta Garcia-Montojo, Sariah J. Allen, Brent A. Orr, Mariarita Santi, Tongguang Wang, Saeed Fathi, Myoung Hwa Lee, Kevon Sampson, Wenxue Li, Zhengping Zhuang, Avindra Nath
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/b606f3bbb7b5473bafc41a2148c765eb
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https://doaj.org/article/b606f3bbb7b5473bafc41a2148c765eb

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